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The degree to which nicotine raises blood pressure is concerning, even when the increase is small

Smoking-induced oxidative DNA damage, chronic inflammation, and impaired immunity combine to promote lung carcinogenesis

Randomization After the 2-week run-in phase, stage 2 will be initiated, in which participants who fail to achieve 7-day abstinence (self-report of not smoking for at least the past 7 days at week 3 study visit) will be randomly assigned to the experimental (group A, escalating active patches) or a control condition (group B, escalating placebo patches) for 10 additional weeks of treatment

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Somewhat on the fence on this, but I find it an interesting debate.