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For example, in these disease models, the dosage of GA ranged from 50 to 100 mg/kg per day, with treatment periods lasting from 4 to 24 weeks

402 : 615622 Onofrj M, Bodis-Wollner I, Pola P, Calvani M

Severe loss of quality of life, due to symptoms such as debilitating fatigue, insomnia (B12 is required for synthesis of melatonin), mental illness, and neurological symptoms

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Ultimately, this process will perturbate mitophagy, and subsequently halts the reticulocyte maturation process, as was observed in models of Gpx4 loss (Figure 1)