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Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease

These represent complementary anti-aging strategies: maintaining healthy cells (Epithalon) versus removing harmful ones (FOXO4-DRI)

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Proceedings of the National Academy of Sciences, USA 106, 77627767

[128:22] Andrew Huberman And in species like dogs, where there's tremendous variation in the amount of IGF one that's made between, say, a Chihuahua and a Great Dane, the breed that makes more IGF1 downstream growth hormone, of course, lives a lot shorter lives than smaller versions of the same species