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Datar S, Corsini E, Mitchell K, Mehran R, Rice D, Sepesi B, Walsh G, Swisher S, Roth J, Vaporicyan A, Hofstetter W, Loree J, Morris V, Antonoff M

Furthermore, mast cells can express co-inhibitory molecules like PD-L1, contributing to the suppression of anti-tumor immune responses and further promoting tumor progression through a complex interplay with the TME [35]

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Theoretical concerns include growth factor-related effects in individuals with existing malignancies and immune modulation in vulnerable populations