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Genetic Factors: Rare genetic conditions such as hereditary transcobalamin deficiency or disorders affecting the production of intrinsic factor can also result in vitamin B12 deficiency

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Involvement of Human Glutathione S-Transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione

doi: 10.1111/j.1399-3054.2006.00815.x

Conclusive remarks The data presented suggest that TGR has a distributive mechanism for the movement of reducing equivalents and that all redox active entities are in constant exchange such that electrons flow forward and backward resulting in staged reduction and reoxidation events that involves multiple redox active groups fractionally at any point in time