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Cell Tissue Res

The synthetic mRNA construct of claim 1, wherein the mRNA construct comprises 5' cap m7GpppGm, a 5' UTR of A1G AT1G58420 (SEQ ID NO: 10), a Kozak sequence (SEQ ID NO: 121), a coding sequence encoding human coagulation factor IX (F9), one 3' UTR of human alpha globin (hAG) (SEQ ID NO: 81), and a poly(A) tail

At the very least, immunogenicity would trigger the production of antibodies that neutralize the peptides effects

We further mutated individual residues at the extracellular end of TM7 from E297 to I300 to proline and measured ghrelin-induced GHSR activation

J Pediatr 1986

Rudmans publication, a lot more research has been undertaken and doses have been reduced somewhat