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Description

The drug amplifies the caloric deficit created by healthy eating and exercise

Its design illustrates a radical peptidomimetic : only two amino acid residues (Tyr-Ile) are preserved from the native peptide, flanked by non-peptide acyl chains to cross biological barriers

doi: 10.7326/M18-2478

Manthey J, Solovei A, Anderson P, Carr S, Rehm J

[PubMed: 17512232] 226

This study uncovers a functional link between altered iSPN BDNF-TrkB signalling, glutathione-ascorbate metabolism and hyperdopaminergic state, underscoring the vital role of GSTO2 in maintaining dopamine balance