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Here are the specific energy and cognitive symptoms that targeted supplementation can address: Profound Fatigue and Post-Exertional Malaise (PEM): By unblocking the methylmalonyl-CoA pathway and feeding succinyl-CoA directly into the mitochondrial Krebs cycle, B12 restores the cellular capacity to generate ATP

B12 is essential for normal function of nerve tissue and is involved in the metabolism of protein, fats, and carbohydrates for ENERGY production and utilization