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Pratic and Sung, 2004

Although the identity of a bona fide lactyltransferase remains undetermined, the acetyltransferase p300 has been suggested as a candidate enzyme capable of mediating both histone (such as H3 and H4) and non-histone lactylation under certain conditions

CHRIS MASTERJOHN: And its just JOE ROGAN: And they work together

186 Interestingly, insulin-induced ROS might induce necrosis by initiating PI3K/AKT, a prosurvival pathway, 187 suggesting context-specific ROS modulation of necroptosis (Fig