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J Kunming Med Univ

Mast cells are innate immune cells that release inflammatory mediators, including histamine, when they detect a threat

Commun, 2020, 11, 119

doi: 10.1111/j.1526-4610.2007.00652.x

Yankner BA

Understanding these metabolic reprogramming processessuch as PDK4-mediated pyruvate dehydrogenase inhibition and PKM2/PKM1 isoform switchingcould identify novel therapeutic targets by regulating key pathways like Anaphase-promoting complex/cyclosome and its coactivator Cdh1 (APC/C-Cdh1)-dependent PFKFB3 stabilization or pentose phosphate pathway activation