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10.1126/science.1198469 21 BahrS

Our results revealed that RGMa-positive cells were in close contact with neogenin-expressing cells within the GCL of db/db mice (Supplementary Fig

Frequency: Once or twice per day (subcutaneous)

Extracellular S has also been shown to regulate transcription factors of Sirts and the upregulation of S increases pro-apoptotic Bax-mediated cell death (Motyl et al., 2018)

Rauen U, Springer A, Weisheit D, Petrat F, Korth H-G, de Groot H, et al

Our structures clearly reveal the ligand-binding pocket for ghrelin, where the peptide moiety of ghrelin mainly occupies cavity I while the octanoyl moiety adopts an extended conformation to occupy cavity II