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Furthermore, to confirm mitochondrial abnormalities, the expression level of genes related to mitochondrial functionoptic atrophy 1 ( OPA1 ), pyruvate dehydrogenase kinase 1 ( PDK1 ), BCL2-interacting killer ( BIK

Mitochondrial failure in OA affects cellular metabolism, resulting in decreased ATP synthesis, increased ROS generation, and altered signaling cascades (101)

Liu MY, Li HM, Wang XY, Xia R, Li X, Ma YJ, Wang M, Zhang HS

AMPK activation suppresses hepatic gluconeogenesis, increases peripheral glucose uptake, and reduces fatty acid synthesis

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