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Protein thiols are also significant targets of reactive oxygen species in vivo

Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intra-tumoral immune signature benefit from pembrolizumab: results from a single-arm phase 2 trial

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As mentioned above, it is well documented across species that prolonged sleep deprivation increases susceptibility to oxidative stress in the form of increased mitochondrial ROS which in turn increases sleep pressure

Among the various natural products, ubiquitous hydroxylated flavonoids have been documented as a potent inhibitor of tyrosinase due to their structural similarities with tyrosinase substrates, such as l-tyrosine and l-DOPA, and substantial antioxidant properties 11,29,30,31