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The larger the volume of a shot, the more pressure effect/tissue stretching effect that may occur and in a sensitive child cause a feeling of discomfort

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Kougioumtzidou et al., 2017)

These mechanisms may have either direct effect on organelles like mitochondria, endoplasmic reticulum, the cytoskeleton, microtubules and nucleus or indirect effect on cellular organelles through the activation and inhibition of signalling kinases, transcription factors and gene-expression profiles

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