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As early as 2009, Shankar had proposed that mitochondria released from necrotic cells activated NLRP3 inflammasome, but the process was inhibited by respiratory chain inhibitors such as rotenone

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[DOI] [PubMed] [Google Scholar] 53.Takada A, Bannai S

Selectively depleting leucine or blocking the neutral amino acid transporter that transports leucine, Slc7a5, impairs mTORC1 activity equivalently to pan-amino acid deprivation