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Remember that clinical trials failed to demonstrate statistically significant weight loss in the largest study, leading to development termination in 2007

Germ-free mice had a higher colonic expression of claudin-1 and occludin as compared with conventional mice, with lower paracellular uptake of a standard probe, suggesting that commensal microbiota controls colonic TJs proteins and paracellular permeability (190)

Methods: The APEX (Autonomic Pupillomotor Exploration in Ischemic Stroke) study is an ongoing prospective observational investigation of AIS patients admitted to a German tertiary stroke center incepted in June 2024

Knowledge on sleep and circadian parameters in some disorders such as bipolar disorders and neurocognitive disorders is robust, and more fragmentary in others, such as eating disorders

patients versus how many European patients were enrolled in the trial

Temporal proteomic profiling of iPSC-derived human liver organoids reveals optimal maturation for drug metabolism and toxicology