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The use of the Nrf2 activator oltipraz effectively inhibits the expression of transferrin receptor (TFR) and divalent metal transporter (DMT1), which in turn suppresses ferroptosis and alleviates depressive symptoms (Zeng et al., 2023)

Of note, 16 patients in the intervention vs 7 in the control cohort achieved a 50% reduction of baseline consumption (p=0.01)

Other mechanisms Neurogenic inflammation in the lung involves airway obstruction, an increase in vascular permeability, extravasation of plasma and leukocytes, mucus hypersecretion and the release of additional inflammatory mediators 84

The most striking protective effects of SGLT2is were a marked reduction in hospitalization for heart failure and a remarkable reduced progression of chronic kidney disease