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1152 Pioglitazone, a PPAR- agonist, has the potential to prevent mitochondrial disruption and intramyocellular lipid imbalance, which are crucial for reversing severe pulmonary arterial hypertension and vascular remodeling

doi:10.3945/ajcn.114.103366

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In addition, as mitochondrial diseases particularly affect tissues and cells that are highly dependent on mitochondrial energy production (such as neuronal, muscle and cardiac cells) (Pfeffer et al., 2013), the use of brain organoids to study the role of mitochondria in neurodevelopmental disorders is a revolutionary strategy

Ekici F, Karson A, Dillioglugil MO, Gurol G, Kir HM, Ates N (2013) The effects of vagal nerve stimulation in focal cerebral ischemia and reperfusion model