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NRF2 activity is also regulated by the availability of many binding partners, including a group of bZIP bi-directional transcription regulators named sMaf proteins (MafF, G and K) [200, 201] which, when bound to NRF2, under OS, favor its maintenance inside the nucleus thereby enhancing its activity [202]

Initial data quality control and threshold settings were performed using the BioMark system Real-Time PCR Analysis software (version 1.0.2

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Gene 95(1):155160

BPC-157, TB-500 and NAD+ act through unrelated pathways targeting different cellular systems [2][16]

Tien, suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-B signaling pathways in chondrocytes and promoting M2 polarization in macrophages