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Notably, the observed downregulation of Metallothionein-2 (Mt2) in the serum proteome results, a well-established inducible antioxidant and metal-chelating protein in serum, strongly supports the interpretation of reduced oxidative stress

and Fridovich I., Subcellular Distribution of Superoxide Dismutases (SOD) in Rat Liver: Cu,ZnSOD in Mitochondria, Journal of Biological Chemistry 276 (2001): 3838838393, 10.1074/jbc.M105395200