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Even when a small fraction does reach the viable epidermis, the molecule has a short functional half-life unless it is stabilized in the formulation (encapsulation, copper chelation, or both) 1

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Consequently, researchers have put forward the concept of combination therapy for cancer treatment, which refers to the therapeutic agents co-administrated for the treatment of cancer ( Although combination therapies contribute to better cancer treatment to some extent, current combination therapies also have many shortcomings: owing to heterogeneity in the physicochemical properties and pharmacokinetics of diverse therapeutic agents, the amount of these therapeutic agents actually reaching the tumor site differs greatly when the prescribed dose is administered, making it difficult to achieve accurate control of the synergistic ratio

Conclusions and future perspectives Although insecticides were once effective in controlling mosquito-borne diseases, the increasing trends of mosquito-borne diseases may indicate an increasing resistance to or ineffectiveness of insecticides in controlling the transmission of the diseases