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This molecular alteration ensures tumor cell survival and proliferation in the microenvironment with low physiological serine concentrations

54 Major additional signaling pathways involved in DNA methylation Important signaling pathways involved in DNA methylation have been described in a review by Hegde and Joshi

PY: pack-years

02 Reduced food cravings The combined effects on the brain's reward centers may help patients better control their food intake and reduce cravings for high-calorie foods

In addition to its critical role in energy metabolism, it acts as an extracellular signaling molecule that binds to and activates its specific G-protein-coupled receptor (GPR91), a receptor in HSCs whose role in hepatic fibrosis remains unclear

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