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Based on this finding, D'Amour et al

Our findings suggest that IgE is required for the development of avoidance behaviour

Optimal dosage follows a narrow window : Men need 55-75 g dailyboth deficiency and excess (over 400 g) can harm reproductive health due to selenium's U-shaped response curve

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Importantly, Huberman strongly recommends doing blood work before and after (~ 8 weeks) supplementation for hormone support to confirm if these supplements are actually effective