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In addition to inducing autophagy at lower concentrations, 4HNE can inhibit autophagic flux at higher concentrations ( Lipid peroxidation is implicated in various kinds of regulated cell death (Su et al., 2019)

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Glutathione has a fundamental, multifunctional role in modulating the redox status of cells, protecting them against oxidants and electrophiles, and detoxifying xenobiotics [14]

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The clinical research currently consists of the following: Small 1980s pilot trials No large modern RCTs Limited pharmacokinetic clarity No validated subcutaneous dosing protocol for improved sleep DSIP likely works for many individuals, but its critical to acknowledge the doses used by the biohacking community comes from extrapolation