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Concomitantly, a phase I clinical trial using NSCs derived from fetal cortices, genetically engineered to overexpressed the trophic factor glial cell line-derived neurotrophic factor (GDNF) [155], will be conducted through Californias stem cell agency ( The transplantation of SOD1 G93A fALS rats using a similar approach protected the integrity of motor neuron cell bodies, but failed to preserve neuromuscular junctions or increase the life-span of the animals [155]

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Due to its simple administration and the low risk of complications, autologous bone marrow applied locally and, in particular, intramuscularly administered osteogenous substances such as TRIS-BPC157, are advantageous over other more complex surgical methods (i.e., bone grafts, vascularized bone grafts, method of Ilizarov) for the treatment of healing impairments in humans

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