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[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Randolph M., Tosti A

10.1016/j.jep.2021.114132 62 GhasemzadehA.JaafarH

Tu C, He J, Wu B, Wang W, Li Z

Research shows injectable B12 achieves serum concentrations 40x higher than equivalent oral doses in deficient patients, explaining its superior clinical outcomes for severe cases

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Animal and in vitro experiments have further verified its barrier repair effect: Butyrate can promote proliferation and mucin secretion of intestinal epithelial cells (IPECs, Caco-2, HT-29), enhance the expression of tight-junction proteins (ZO-1, Claudin-1, Claudin-2), and maintain colonic mucosal integrity (82)