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Changes in the Intracellular Signaling Cascades It is becoming increasingly evident that current mood-stabilizing agents have actions that extend beyond binding to neuronal membrane surface receptors

These results demonstrated that foliar application of melatonin improved photosynthetic capacity and reduced the oxidative damage in Salvia species under water stress conditions, and supported the hypothesis that exogenous application of melatonin could effectively enhance stress tolerance in plants 54,55

Fickert P, Hirschfield GM, Denk G, Marschall HU, Altorjay I, Frkkil M, et al

Thus, aging, by reducing rhythm robustness and metabolic flexibility, weakens the organisms temporal adaptation mechanisms and increases its vulnerability to external factors that induce circadian misalignment, while chronodisruption itself exacerbates this susceptibility, creating a self-reinforcing loop

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Feng, M., Xiong, G., Cao, Z., Yang, G., Zheng, S., Qiu, J., You, L., Zheng, L., Zhang, T., & Zhao, Y