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The NO/cGMP/PKG pathway in platelets: the therapeutic potential of PDE5 inhibitors in platelet disorders

Unlike eukaryotic cells, most known bacterial cuproproteins are located within the cytoplasmic membrane or in the periplasmic space, perhaps to compartmentalize a potentially toxic metal species

A treatment strategy designed to significantly delay the symptoms and pathology of this disease could maintain the patients quality of life and reduce health care costs

This is called enterohepatic circulation, and it is for this reason that a deficiency due to dietary absence can take years to develop if there are sufficient reserves even in the absence of dietary intake, since it generally starts from a high pool and very small daily losses if the reabsorption mechanism is working at peak efficiency

Atherosclerosis 129 , 149157 (1997)