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Pharmacological inhibition of GPX4 accelerates motor neuron degeneration and death (366, 367, 369), whereas GPX4 overexpression delays disease onset, improves motor function, and prolongs survival (368, 371)

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At the molecular level, 6-hydroxydopamine treatment has been observed to increase the levels of mRNA for Il-6 , Tnf- , and NF- , while decreasing the protein expression of GPX-1 and COX-2 in the PFC [101]

At the later time points, 3 and 6 h after APAP, both plasma miR-122 and ALT started to increase, while the fold change of miR-122 is larger than of ALT (Fig