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Because GH and IGF-1 promote protein synthesis and lipolysis, these hormonal changes provide a plausible mechanistic basis for modest increases in lean body mass, improved recovery and support for fat loss seen in clinical and observational contexts, but robust controlled trials explicitly measuring those endpoints are still lacking

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GLOW is usually aligned with collagen and tissue remodeling research models, while KLOW is often chosen when researchers want broader pathway coverage that includes inflammation-response signaling (due to the inclusion of KPV)

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