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(2006) Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis

Notably, a cross-sectional study highlighted that individuals with depression, particularly those with anhedonia, showed a higher occurrence of metabolic syndrome (183, 184)

19 However, therapeutic goals during early-stage CD differ considerably compared with treatment goals for late-stage disease

However, the diversity and heterogeneity of the research population must be considered, such as age, gender, ethnicity and any comorbidities

doi: 10.3389/fphys.2021.720639 309 TooleyK

[147] Additionally, zebrafish may exhibit AD-like cognitive and behavioral manifestations that can be further explored in drug screening to identify potential treatments for AD [150, 151]