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2024;47:S23143

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The studies also had some shortcomings, as some only administered fluoxetine at the end of pregnancy and could not assess the effects of the drug throughout the entire pregnancy period, some did not explore the specific mechanisms of fluoxetine-induced fetal acidosis, hypocalcemia, and altered maternal estradiol metabolism, and some failed to assess the maternal and fetal health status over a long-term follow-up period

Gene-expression modulation: the systemic reset hypothesis The most ambitious mechanistic claim and the one most specific to systemic delivery is that GHK acts as a genome-level modulator

Loss of FSP1 does not affect System Xc- or glutathione synthesis but, even in the presence of functional GPX4, results in elevated phospholipid oxidation ( 2.1.3.4 Other molecular mechanisms In addition to GPX4, several regulatory pathways, including the PERK-NRF2-HO-1, AMPK/GSK-3/NRF2, and HSF1-HSPB1 axes, play critical roles in modulating ferroptosis independently of the GPX4 system