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Assays and studies on the tongues of irradiated rats showed that mitochondrial ROS production plays a role in mucositis and is influenced by the NF-kappa-B and NLRP3 activation (both are known to activate inflammatory pathways that increase the expression of genes responsible for causing mucositis) [49]

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Notably, in vitro studies revealed that polystyrene MPs could enter Leydig, Sertoli, and germ cells, indicating that these reproductive abnormalities could be caused by direct cellular contacts