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Enzymology of mammalian NAD metabolism in health and disease

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10.3389/fphar.2020.00907 Front

Expert Opin Drug Metab Toxicol 8 , 909920, (2012)

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91 TGF- promotes EndMT in PH Canonical pathway In MCT-PAH rats, upregulation of TGF- and increased phosphorylation of Smad2 leads to elevated expression of Gal-3 and -SMA, facilitating EndMT