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[DOI] [PMC free article] [PubMed] [Google Scholar] 161.Bontemps F, Van Den Berghe G

How to distinguish between lethal mitochondrial damage that leads to neuronal death and potentially reversible sublethal dysfunction

And I take that a little bit more literally

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In 206.3243 cybrid cells, a 95% mutational burden led to an 75% reduction in cytochrome c oxidase activity, whereas a lower (85%) mutation burden in a different nuclear background (i.e., B2.3243) caused greater reduction (85%) in activity