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E2 further upregulates key mitochondrial antioxidant enzymes, including SOD2, GPx and catalase, thereby enhancing ROS-scavenging capacity (109)

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In contrast to cytochromes P450, the active site of these enzymes is embedded in the lumenal part of ER

Glutathione is most concentrated in the liver and is essential in helping the liver detox." Patel continues, "Since glutathione plays a role in balancing free radicals and removing toxins in the body, it helps keep the body balanced from oxidative stress damage

The standard treatment, recombinant tissue-type plasminogen activator (rt-PA), is effective initially, but its efficacy declines rapidly over time as the risk of complications, such as hemorrhagic transformation and blood-brain barrier dysfunction, increases