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Selenium has a narrow safe window, the NHS flags 350 g/day from supplements as the level unlikely to cause harm, and the UK Safe Upper Level is 450 g/day from all sources

This dual demand greatly increases your liver metabolic load, as both substances compete for the same cytochrome P450 enzymes , particularly CYP2C9 and CYP3A4

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et al.: Glucose Measurement and Control in Patients with Type 1 or Type 2 Diabetes

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Chen T-S, Huang T-H, Lai M-C, Huang C-W (2023) The role of glutamate receptors in Epilepsy