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46 GENERATION AND CHARACTERIZATION OF A HUMANIZED MOUSE MODEL OF ALCOHOL INDUCED STEATOSIS, INFLAMMATION AND FIBROSIS Eleanna Kaffe and Wajahat Z

Brunkow, S

Overall, the data available shows that NQO1 overexpression favors the activation of metabolic mechanisms that counteract the damaging effects of lipid oversupply

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These alterations, secondary to heat damage, lead to increased concentrations of endotoxin and reactive oxygen species (ROS) [52], promoting significant damage to the intestinal mucosa by disrupting cellular membranes and the tight junctions [42]

In addition to serving as an energy supply, KBs also serve as substrates for the production of lipids in the brain, such as myelin (Cunnane and Crawford, 2014)