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Additionally, this group demonstrated significant decreases in blood cadmium levels and in the following enzymes: alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase

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For topical applications, mild irritation, redness, or itching at the application site are the most commonly reported observations

doi: 10.1126/science.aaf6284 14 MichalekRDet al

It has been reported that when ferroptosis occurs in neurons, then microglia are activated and release toxic substances including pro-inflammatory factor IL-6, which can cause neuro-inflammation and lead to further brain damage (Tang et al., 2020)