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In: McManus LM, Mitchell RN (eds) Pathobiology of Human Disease

Bidirectional signaling further reinforces this crosstalk: tumor-cellderived lactate, HMGB1, prostaglandins, and oxidized lipids polarize macrophages toward either ferroptosis-promoting (M1-like) or ferroptosis-restraining (M2-like) states

Major exceptions to these patterns are the middle reaches of the Cavalla and Dugbe Rivers in eastern Liberia, which flow parallel to the coast in their lower reaches before entering the Atlantic Ocean

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This process is also linked to pigmentation

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