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They were then stimulated with TNF- for 6 h prior to treatment with different formulations (USPB, SeDMSN, USPB@SeDMSN, and USPB@SeDMSN@NM)

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Methionine S-adenosyl methionine (SAM), a methionine metabolite, may interact with opioids, antipsychotics, amphetamines, and antidepressants to cause an overabundance of serotonin to accumulate in the body