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First-in-elephant, proof-of-concept vaccination study Study design Study elephants Equivalent to phase I vaccine trial standards, healthy adult elephants rather than EEHV-susceptible calves were chosen for this first-in-elephant proof-of-concept study

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283,284,285 PEG modification can inhibit the binding of apolipoprotein E to LNPs, a key mechanism for LNP uptake by the liver, thereby affecting liver uptake of LNPs