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Ethics declarations Ethics approval and consent to participate The experiment research protocol was approved by the Ethics Committee of Guizhou Provincial Peoples Hospital all experimental procedures conformed with institutional guidelines, All procedures and animal care were approved by Guizhou Provincial Peoples Hospital Animal Care Committee and performed according to NIH guidelines (Ethics approval number: 201710-ZX6602)

10.1080/13813455.2018.1437186 91 SharmaR.BrownD.AwasthiS.YangY.SharmaA.PatrickB.et al (2004)

Nicotinamide adenine dinucleotide and its role in health and disease (2021)

S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans

To reinforce these findings, we investigated changes in extracellular vesicle concentrations in ascitic fluids before and after therapy using nanoparticle tracking analysis (NTA)