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Interactions with other medications have not been systematically characterized potential interactions with CNS depressants (alcohol, sedatives, anxiolytics), opioids, or other psychoactive substances should be considered, though documented problematic interactions are not prominent in available literature

It appears that the anti-inflammatory effects may be primarily due to inhibition of the COX-2 isoenzyme

This matters especially for long-duration studies where consistent compound performance across experimental timepoints is critical

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Wound healing assay 3 10 3 HUVECs were grown to confluence in 96-well plate