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doi: 10.1039/ct8946500899 29 FoyerC

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

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Injectable and IV routes dominate because standard oral glutathione has very low bioavailability it's largely degraded in the gut before reaching circulation

Moreover, GSH serves not only as a reductant for GPxs, but also as a co-substrate for other antioxidant enzymes such as glutathione-S-transferases (GSTs) (Nobili et al