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In its active state, it binds and activates its effector proteins such as RAF-Kinases, PI3K and RalGDS and activates several cellular signaling pathways including mitogen-activated protein kinase (MAPK) pathway

Luminescence was read by a victor3 1420 multilabel counter (Perkin Elmer)

6) as opposed to the reduction of the glutathionylated monothiol roGFP2 variants (Fig

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However, the high chloride content compared to normal blood levels of about 100 milliequivalents per liter can cause metabolic acidosis when large volumes are given