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Bowling AC, Schulz JB, Brown RH Jr, Beal MF

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However, this mechanistic promise fails to translate clinically: the phase III ECHO-301 trial (NCT02752074), a randomized double-blind study of 706 melanoma patients, showed that combining the IDO1 inhibitor epacadostat with pembrolizumab yielded no significant improvements in PFS or OS compared to pembrolizumab monotherapy (250)