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The effect of cryopreservation on the genome of gametes and embryos: principles of cryobiology and critical appraisal of the evidence

10.1016/j.cell.2005.06.022 Summary Keywords kinase, mitochondrial morphology, mitochondria, apoptosis, mitochondrial associated endoplasmic reticulum membranes (MAMs), reactive oxygen species (ROS), disease adaptation Citation Skalka GL, Tsakovska M and Murphy DJ (2024) Kinase signalling adaptation supports dysfunctional mitochondria in disease

Brain 143, 396406

PMID 24828577

It is critical to verify whether the changes reported in different research are consistent as a potential biomarker

The second mechanism is through the interaction between glutamate and the cystine transporter, which reduces intracellular glutathione (GSH) and increases ROS accumulation