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Some of these are small molecules that specifically inhibit the different protein complexes of the ETC, while uncoupler proteins or molecules create holes in the membrane and destroy the H+ gradient resulting from electron flow through complex I, III, and IV of the ETC

A great deal of effort has been focused on releasing the feedback inhibition caused by GSH

doi: 10.1245/s10434-018-6662-8 133 MontfortAPearceOManiatiEVincentBGBixbyLBohmSet al

Consistent with the finding that there is no apparent increase in enzymatic activity, the transcript levels of genes encoding -glutamylcysteine synthetases did not change significantly either

They are important for DNA synthesis and fatty acid and amino acid metabolism