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Cardiac-specific deletion of MED13 increases susceptibility to obesity, whereas its overexpression promotes a lean phenotype

Furthermore, while Tozasertib demonstrated strong efficacy at modest doses, its previously reported cardiotoxicity, myelosuppression, and limited data on brain penetrance warrant cautious interpretation of its translational potential 83

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In accordance, newborns with mutations in the GH Releasing Hormone Receptor (GHRHR) gene resulting in an isolated GH deficiency (GHD) phenotype was associated with normal birth weight in one cohort (53) and slightly subnormal birth weight in another (54)

Come con qualsiasi trattamento, i risultati e i potenziali effetti collaterali della terapia peptidica variano da persona a persona